Matthew Perry Froze Up From Ketamine Injection Weeks Before Death

Matthew Perry had a scary reaction to ketamine weeks before he died from the acute effects of it … with prosecutors claiming an injection caused him to freeze up.

During the U.S. Attorney’s news conference Thursday, prosecutors claimed Dr. Salvador Plasencia came to the actor’s residence a little over 2 weeks before his death on Oct. 28, 2023, and administered a rather large dose of ketamine via injection.

Prosecutors say the injection caused Perry’s blood pressure to spike and made him freeze up … which apparently freaked out Plasencia so much he told Perry’s assistant, Kenneth Iwamasa, they should not administer a dose that large again.

But, prosecutors claim the 2 men didn’t stop injecting Perry altogether — they assert Iwamasa injected his boss close to 30 times in the days leading up to his death, and Plasencia even met Perry in a Long Beach parking lot to administer ketamine.

Both doctors were charged yesterday in connection to his death, along with Iwamasa, an alleged drug broker named Erik Fleming and Jasveen Sangha … the woman who’s been dubbed the “Ketamine Queen of Los Angeles.”

As we’ve reported, Plasencia allegedly expressed a desire to upcharge Perry a ton for the drug, texting his other defendants, “I wonder how much this moron will pay” … in reference to Matthew.

Plasencia and Sangha pled not guilty Thursday and their trials are set for October. Chavez, Fleming and Iwamasa have all struck plea deals.